RNA-based Regulation in Human Health and Disease offers an in-depth exploration of RNA mediated genome regulation at different hierarchies. Beginning with multitude of canonical and non-canonical RNA populations, especially noncoding RNA in human physiology and evolution, further sections examine the various classes of RNAs (from small to large noncoding and extracellular RNAs), functional categories of RNA regulation (RNA-binding proteins, alternative splicing, RNA editing, antisense transcripts and RNA G-quadruplexes), dynamic aspects of RNA regulation modulating physiological homeostasis (aging), role of RNA beyond humans, tools and technologies for RNA research (wet lab and computational) and future prospects for RNA-based diagnostics and therapeutics. One of the core strengths of the book includes spectrum of disease-specific chapters from experts in the field highlighting RNA-based regulation in metabolic & neurodegenerative disorders, cancer, inflammatory disease, viral and bacterial infections. We hope the book helps researchers, students and clinicians appreciate the role of RNA-based regulation in genome regulation, aiding the development of useful biomarkers for prognosis, diagnosis, and novel RNA-based therapeutics.

1. Introduction2. Non-coding RNAs: ever-expanding diversity of types and functions3. Functional categories of RNA regulation4. The dynamic aspects of RNA regulation5. RNA beyond humans6. Extracellular RNA in human health and disease7. RNA and malaria pathogenesis8. RNA and metabolic disorders9. RNA toxicity in tandem nucleotide repeats mediated neurodegenerative disorders10. Regulation by non-coding RNAs in respiratory disorders11. RNA in cancer12. RNA and inflammatory autoimmune diseases13. RNA and bacterial infection14. RNA and stress15. RNA and aging16. Experimental toolkit to study RNA level regulation17. Industry perspective18. Summary and future perspectives