Neural Mechanisms of Addiction is the only book available that synthesizes the latest research in the field into a single, accessible resource covering all aspects of how addiction develops and persists in the brain. The book summarizes our most recent understanding on the neural mechanisms underlying addiction. It also examines numerous biobehavioral aspects of addiction disorders, such as reinforcement learning, reward, cognitive dysfunction, stress, and sleep and circadian rhythms that are not covered in any other publication. Readers with find the most up-to-date information on which to build a foundation for their future research in this expanding field.

1. IntroductionMary M. Torregrossa2. Animal Models of AddictionRita A. Fuchs3. Transcriptional and Epigenetic Regulation of Reward Circuitry in Drug AddictionA.J. Robison4. Neural Circuit Alterations in AddictionMatt Hearing and Eden Marie Anderson5. Glutamatergic Neuroplasticity in AddictionL. A. Knackstedt and Allison Bechard6. Neural Ensemble Encoding of Addictive BehaviorBruce Hope7. Interoceptive Stimulus Effects of Drugs of AbuseJennifer Murray8. Maladaptive Memory Mechanisms in Addiction and RelapseMary M. Torregrossa9. Neural Morphology and AddictionPatrick Mulholland10. Mechanisms regulating compulsive drug behaviorsDavid M. Dietz11. Role of Stress-Associated Signaling in AddictionJohn Mantsch and Elizabeth M. Doncheck12. Negative Reinforcement Mechanisms in AddictionOlivier George13. Circadian Rhythms and AddictionRyan Logan14. Role of Oxytocin in Countering Addiction-Associated Behaviors Exacerbated by StressJacqueline McGinty15. The Role of Norepinephrine in Addiction: Past, Present, and FutureDavid Weinshenker16. Glial Dysregulation in AddictionDavid Baker17. Role of the Extracellular Matrix in AddictionPeter W. Kalivas and Lauren Beloate18. Striatal cell-type specific plasticity in addictionMary Kay Lobo19. Harnessing Circuits for the Treatment of Addictive DisordersChristelle Baunez20. Conclusions and Future DirectionsMary M. Torregrossa