Introduction to Biological and Small Molecule Drug Research and Development provides, for the first time, an introduction to the science behind successful pharmaceutical research and development programs. The book explains basic principles, then compares and contrasts approaches to both biopharmaceuticals (proteins) and small molecule drugs, presenting an overview of the business and management issues of these approaches. The latter part of the book provides carefully selected real-life case studies illustrating how the theory presented in the first part of the book is actually put into practice. Studies include Herceptin/T-DM1, erythropoietin (Epogen/Eprex/NeoRecormon), anti-HIV protease inhibitor Darunavir, and more.

1. 'Introduction to Enzymes, Receptors and Small Molecule Drugs' 2. Proteins: Structure and Function                                                                     3. The Drug Discovery Process - from Target Selection to Candidate              4. Introduction to Biopharmaceuticals                     5. Similarities and Differences in the Discovery, Development and Use of Biopharmaceuticals versus Small Molecule Drugs                                                                                           6. 'Approaching the Same...Treatment of Diabetes7. The Structure and Business of Bio/pharmaceutical Companies including the Management of Risks and Resources 8. Gefitinib  9. Herceptin/T-DM1 10. Erythropoietin (Epogen/Eprex/NeoRecormon) 11. Lysosomal Storage diseases 12. Steroids for HRT13. Anti-HIV protease inhibitor Darunavir  14. Anti-TNF Agents Remicade/Humira/Enbrel/Cimzia15. The Cholesterol Lowering Drug - Ezetimibe