This new volume of Current Topics in Developmental Biology covers Stem Cells in Development and Disease. The chapters provide a comprehensive set of reviews covering such topics as the mechanisms of pluripotency in vivo and in vitro, hematopoietic stem cell development, intestinal stem cells and their defining niche, epithelial stem cells in adult skin, the mammary stem cell hierarchy, satellite cells, neural stem cells of the hippocampus, lung stem and progenitor cells in tissue homeostasis and disease, spermatogonial stem cell functions in physiological and pathological conditions, the origin, biology, and therapeutic potential of facultative adult hepatic progenitor cells, nephron progenitor cells, adult stem cell niches, cancer stem cells, pluripotency and cellular heterogeneity, and cellular mechanisms of somatic stem cell aging

1. Mechanisms of Pluripotency In Vivo and In Vitro2. Hematopoietic Stem Cell Development: An Epigenetic Journey3. Intestinal Stem Cells and their Defining Niche4. Epithelial Stem Cells in Adult Skin5. The Mammary Stem Cell Hierarchy6. Satellite Cells: The Architects of Skeletal Muscle7. Neural Stem Cells of the Hippocampus: Development, Physiology Regulation and Dysfunction in Disease8. Lung Stem and Progenitor Cells in Tissue Homeostasis and Disease9. Spermatogonial Stem Cell Functions in Physiological and Pathological Conditions 10. The Origin, Biology, and Therapeutic Potential of Facultative Adult Hepatic Progenitor Cells11. Nephron Progenitor Cells: Shifting the Balance of Self-Renewal and Differentiation12. Adult Stem Cell Niches: Cellular and Molecular Components13. Cancer Stem Cells, Pluripotency, and Cellular Heterogeneity: A WNTer Perspective14. Cellular Mechanisms of Somatic Stem Cell Aging