Dynamics of Bone and Cartilage Metabolism
Principles and Clinical Applications
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ISBN-13:
9780120885626
Veröffentl:
2006
Erscheinungsdatum:
24.07.2006
Seiten:
920
Autor:
Markus J Seibel
Gewicht:
2368 g
Format:
279x220x38 mm
Sprache:
Englisch
Beschreibung:
This updated edition is a comprehensive treatise that spans the complete range of basic biochemistry of bone and cartilage components to the clinical evaluation of disease markers in bone and joint disorders. With contributions from over 75 international experts, this latest edition is indispensable reading for those involved in skeletal research as well as for rheumatologists, endocrinologists, clinical biochemists, and other clinical disciplines participating in the management of patients with bone and cartilage diseases. *Part I provides an up-to-date account of current knowledge of the structure, biosynthesis and molecular biology of the major tissue components*Part II covers the organizational structure and cellular metabolism of bone and cartilage*Part III deals with the utility of components specific to bone and cartilage as biomarkers of health and disease
PART I Components of the Organic Extracellular Matrix of Bone and Cartilage 1. Structure, Biosynthesis and Gene Regulation of Collagens in Cartilage and Bone 2. Fibrillogenesis and Maturation of Collagens 3. Vitamin K Dependent Proteins of Bone and Cartilage 4. Non-collagenous Proteins; Glycoproteins and Related Proteins 5. Proteoglycans and Glycosaminoglycans 6. Growth Factors 7. Prostaglandins and Proinflammatory Cytokines 8. Integrins and Other Adhesion Molecules 9. Alkaline Phosphatases 10. Acid Phosphatases 11. Matrix Proteinases
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