Immunology, the third volume in the four volume set, The Mouse in Biomedical Research, is a completely new addition to this series, dedicated to mouse immunology. It is based on the vast body of knowledge which has made the mouse the model of choice when studying immunity in man. Arguably more is known about the immune system in mice than any other species except man. In large part this is due to the power of genetic engineering to delineate molecular mechanisms. In this volume we present an Overview to mouse immunology, including both the innate and adaptive immune systems, followed by 15 chapters, each dealing with a specific area of immunology in the mouse. These chapters illustrate the power of genetic engineering in dissecting each component of the immune response from the development of lymphoid tissues to signal transduction pathways in activated cells.

1. The Molecular Basis of Lymphoid Architecture in the Mouse2. The Biology of Toll-like Receptors in Mice3. Genomic Organization of the Mouse Major Histocompatibility Complex4. Some Biological Features of Dendritic Cells in the Mouse5. Mouse Models Revealed the Mechanisms for Somatic Hypermutation and Class Switch Recombination of Immunoglobulin Genes6. Mouse Natural Killer Cells: Function and Activation7. Cytokine-activated JAK-STAT Signaling in the Mouse Immune System8. Signal Transduction Events Regulating Integrin Function and T Cell Migration in the Mouse9. Mouse Models of Negative Selection10. Peripheral Tolerance of T Cells in the Mouse11. The Genetics of Mouse Models of Systemic Lupus12. Inhibitory Receptors and Autoimmunity in the Mouse13. Mouse Models of Immunodeficiency14. Mouse Models to Study the Pathogenesis of Allergic Asthma15. The Mouse Trap: How Well Do Mice Model Human Immunology?