This handbook focuses on the entire development process of biomedical microsystems that promote special interactions with cells. Fundamentals of cell biology and mechanobiology are described as necessary preparatory input for design tasks. Advanced design, simulation, and micro/nanomanufacturing resources, whose combined use enables the development of biomedical microsystems capable of interacting at a cellular level, are covered in depth. A detailed series of chapters is then devoted to applications based on microsystems that offer enhanced cellular control, including microfluidic devices for diagnosis and therapy, cell-based sensors and actuators (smart biodevices), microstructured prostheses for improvement of biocompatibility, microstructured and microtextured cell culture matrices for promotion of cell growth and differentiation, electrophoretic microsystems for study of cell mechanics, microstructured and microtextured biodevices for study of cell adhesion and dynamics, and biomimetic microsystems (including organs-on-chips), among others. Challenges relating to the development of reliable in vitro biomimetic microsystems, the design and manufacture of complex geometries, and biofabrication are also discussed.

Some introductory notesto cell behavior.- Brief introduction to the field of biomedical microsystems.- Briefintroduction to bio-microsystems for interacting with cells.- Common bioengineering resources for interacting with cells.- Methodologiesfor the development of bio-microsystems.- Addressing the complexity ofbiomaterials by biomimetic CAD.- Multi-scale andmulti-physical/biochemical modeling in bio-MEMS.- Rapid prototyping ofbio-MEMS for interacting with cells.- Nanomanufacturing for biomedicalMEMS.- Issues linked to the mass-production of biomedical microsystems.- Biomedicalmicrosystems for disease management.- Overview of microsystems forstudying cell behavior under culture.- Microsystems forstudying cell adhesion, dynamics and and overallmechanobiology.- Smart microsystems for active cell culturetoward relevant tissues.- Tissue engineering scaffolds for 3D cellculture.- Tissue engineering scaffolds for bone repair: General aspects.- Tissueengineering scaffolds for bone repair: Dental repair.- Tissue engineeringscaffolds for repairing soft tissues.- Tissue engineering scaffolds forosteochondral repair.- From labs-on-chips to microfluidic cell culture.- Cell-basedsensors and cell-based actuators.- Towards reliable organs-on-chips andhumans-on-chips.- Towards effective and efficient biofabricationtechnologies.- Project-based learning in the field of biomedicalmicrosystems.- Annexes.