The isolation of leptin in 1994 and its characterization as a factor influencing appetite, energy balance, and adiposity, immediately thrust the polypeptide into the rapidly growing body of literature centered on the physiology of obesity. The growing clinical awareness of obesity as a major health risk in developed societies dovetailed perfectly with any of a number of roles that leptin might play in this abenant physiological condition. Almost unnoticed amidst the excitement generated by early leptin publications was the suggestion that the "fat hormone" might also regulate a wide range of systems and events important to reproduction, including pubertal development, gonadal endocrinology, fettility, and pregnancy. Recognizing this potential, a relatively small cadre of researchers began to examine leptin specifically as a reproductive hormone, thus creating a new and fertile field of investigation. Interest in this area has since gained momentum and an increased number of participants have now made significant contributions to our understanding of many leptin-related mechanisms that are relevant to reproductive biology. Leptin and Reproduction is the first major volume to specifically address leptin as a reproductive hormone and closely examines the advances made in the short time since this field of interest developed. Preeminent researchers ti'om many of the subdisciplines working within this area present a welcomed compendium of the wealth of related literature and voice novel interpretations of cun'ent advances.

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Introduction. 1. Leptin: From Satiety Signal to Reproductive Regulator; M.C. Henson, et al.General Reproductive Function. 2. Neuroendocrine Regulation of Leptin Secretion and its Role in Nitric Oxide Secretion; S.M. McCann, et al. 3. Endocrine Regulation of Leptin Production; R.V. Considine. 4. Regulation and Roles of Leptin During the Menstrual Cycle and in Menopause; I. Messinis, E. Domali. 5. Impact of Leptin on Ovarial Folliculogenesis and Assisted Reproduction; J.D. Brannian, K.A. Hansen. 6. The Effect of Leptin on Ovarian Steroidogenesis; L.J. Spicer. 7. Regulation of Leptin and Leptin Receptor in the Human Uterus: Possible Roles in Implantation and Uterine Pathology; V.D. Castracane, M.C. Henson. 8. Leptin and Reproduction in the Male; J. Lado-Abeal, R.L. Norman.Puberty. 9. Leptin and Pubertal Development in Higher Primates; D.R. Mann, T.M. Plant. 10. Leptin and Pubertal Development; S. Blüher, C.S. Mantzoros. 11. Interaction of Leptin with Other Signals Regulating the Timing of Puberty: Lessons Learned from the Sheep Model; D.L. Foster, L.M. Jackson.Pregnancy. 12. Leptin and Fetal Growth and Development; H. Christou, C.S. Mantzoros. 13. Leptin in the Placenta; B.J. Waddell, J.T. Smith. 14. Leptin in Rodent Pregnancy; B.J. Waddell, J.T. Smith. 15. Leptin in Primate Pregnancy; M.C. Henson, V.D. Castracane.Genetics. 16. Genetics and Physiology Link Leptin to the Reproductive System; F.F. Chehab, et al. 17. Leptin and the Onset of Puberty: Insights from Rodent and Human Genetics;I. Sadaf Farooqi.Clinical Challenges. 18. Does Leptin Play a Role in Pre-Eclampsia? L. Poston. 19. Leptin and the Regulation of Hypothalmic Amenorrhea; M.P. Warren, J.E. Dominguez. 20. The Role of Leptin in Polycystic Ovary Syndrome; D.A. Magoffin, et al.