Lung cancer is the leading cause of cancer related mortality. Metastatic lung cancer is responsible for more than ninety percent of lung cancer related deaths. However, relatively little progress has been made in understanding the process of lung cancer metastasis. The two main aims of this book are a) to introduce clinical aspects to basic scientists and basic molecular and cellular concepts to clinical investigators, in order to promote collaboration and foster much needed translational research; and b) to introduce new and emerging concepts and approaches in metastasis research to lung cancer research community at large. In this attempt, the book will cover a broad spectrum of subjects ranging from the current trends in the clinical management of the metastatic disease, to the systems biology approach for gaining insights into the mechanisms of metastasis. Some of the subjects covered will include: defining basic hallmarks of a metastatic cell, the concept of tumor stem cells, epithelial-mesenchymal transitions, evasion of immune-surveillance, tumor-stromal interactions, angiogenesis, molecular imaging and biomarker discovery.

Lung cancer is the leading cause of cancer-related mortality. Metastatic lung cancer is responsible for more than ninety percent of lung cancer related deaths. However, relatively little progress has been made in understanding the process of lung cancer metastasis. The two main aims of this book are a) to introduce clinical aspects to basic scientists and basic molecular and cellular concepts to clinical investigators, in order to promote collaboration and foster much needed translational research; and b) to introduce new and emerging concepts and approaches in metastasis research to lung cancer research community at large.In this attempt, the book will cover a broad spectrum of subjects ranging from the current trends in the clinical management of the metastatic disease, to the systems biology approach for gaining insights into the mechanisms of metastasis. Some of the subjects covered will include: defining basic hallmarks of a metastatic cell, the concept of tumor stem cells, epithelial-mesenchymal transitions, evasion of immune-surveillance, tumor-stromal interactions, angiogenesis, molecular imaging and biomarker discovery.

1. Lung Cancer: Overview Shirish M. Gadgeel and Gregory P. Kalemkerian Hallmarks of Metastasis M. Roshni Ray, and David M. Jablons Tumor stem cells and Metastasis Jaclyn Y. Hung Epithelial-mesenchymal Transition as a Mechanism of Metastasis Katia Savary1, Stefan Termén1, Sylvie Thuault1, Venkateshwar G. Keshamouni2 and Aristidis Moustakas Mechanisms of Tumor Cell Migration and Invasion in Lung Cancer Metastasis Charles Kumar Thodeti* and Kaustabh Ghosh 6. Immunologic Mechanisms in Lung Carcinogenesis and Metastasis Jay M. Lee, Jane Yanagawa, Saswati Hazra, Sherven Sharma, Tonya Walser, Edward Garon, and Steven M. Dubinett Angiogenesis and Angiogenic Diversity in Lung Cancer Metastasis Douglas A. Arenberg 8. Chemokines in Lung Cancer Metastasis Borna Mehrad, Ellen C. Keeley, and Robert M. Strieter Molecular Control of Lymphatic Metastasis in Lung Cancer Mark M. Fuster and Judith A. Varner Carcinoma Associated Fibroblasts in Lung Cancer Roya Navab Ph.D., Bizhan Bandarchi M.D. and Ming-Sound Tsao M.D 11. The role of tumor associated macrophages and other innate immune cells in metastatic progression of lung cancer Zvi G. Fridlender, M. Cecilia Crisanti and Steven M. Albelda 12. Experimental Animal Models for Studying Lung Cancer Jiang Liu M.D. and Michael R. Johnston 13. Molecular Imaging in Lung Cancer Metastases Mahaveer Swaroop Bhojani, Shyam Nyati, Hyma R Rao, Brian D Ross and AlnawazRehemtulla 14. Biomarker Discovery For Metastatic Disease Gilbert S. Omenn and James D. Cavalcoli 15. Current Clinical Management of Metastatic Lung Cancer Bryan J. Schneider and Suresh S. Ramalingam 16. Site-Directed Therapy For Lung Cancer Metastases Kevin S. Oh, Baskaran Sundaram, Venkataramu Krishnamurthy, Allan Pickens, Malini Venkatram, Ella A. Kazerooni, Charlie Pan, and James Hayman 17. Systems Approach for Understanding Metastasis Peter J. Woolf , Angel Alvarez and Venkateshwar G. Keshamouni