Since the first edition of this highly acclaimed text was published in 1992, much new knowledge has been gained about the role of genetic factors in common adult diseases, and we now have a better understanding of the molecular processes involved in genetic susceptibility and diseasesmechanisms. The second edition fully incorporates these advances. The entire book has been updated and twelve new chapters have been added. Most of these chapters deal with diseases such as gallstones, osteoporosis, osteoarthritis, skin cancer, other common skin diseases, prostate cancer andmigraine headaches that are seen by all physicians. Others address the genetic and molecular basis of spondylarthropathies, lupus, hemochromatosis, IgA deficiency, mental retardation, hearing loss, and the role of mitochondrial variation in adult diseases. Chapters on the evolution of humangenetic disease and on animal models add important background on the omplexities of these diseases. Unique clinical applications of genetics to common diseases are covered in the additional new chapters on genetic counseling, pharmacogenetics, and the genetic consequences of moderntherapeutics.

The only comprehensive volume on genetic factors in common adult diseases

PART 1: APPROACHES; 1. Approach to Genetic Bases of Common Diseases; 2. Molecular Genetics of Common Diseases; 3. Genetic Epidemiologic Methods; 4. Evolution of Human Genetic Diseases; 5. Animal Models of Complex Genetic Disease; 6. Genetic Counselling: History, Risk Assessment, Strategies and Ethical Considerations; PART 2: CARDIOPULMONARY DISEASES; 7. Genetics of Coronary Atherosclerosis; 8. Hypertension; 9. Chronic Obstructive Pulmonary Disease; PART 3: IMMUNOLOGIC AND INFECTIOUS DISEASES; 10. Genetics of Human Susceptibility to Infectious Diseases: Progress and Prospects; 11. Genetics of Asthma and Bronchial Hyperresponsiveness; 12. IgA Deficiency and Common Variable Immunodeficiency; PART 4: GASTROINTESTINAL DISORDERS; 13. Peptic Ulcer and Gastritis; 14. Lactase Deficiency: Biological and Medical Aspects of the Adult Human Lactase Polymorphism; 15. Inflammatory Bowel Disease; 16. Gallstones; 17. Chronic Liver Disease; 18. Hereditary Hemochromatosis; 19. Gluten-Sensitive Enteropathy; PART 5: ENDOCRINE DISORDERS; 20. Thyroid Disease; 21. Type 1 Diabetes Mellitus; 22. Type 2 Diabetes Mellitus; 23. Obesity; 24. Genetics of Osteoporosis; 25. Hyperuricemia and Gout; PART 6: GENITOURINARY DISEASES; 26. Gynaecologic Disorders; 27. Infertility and Pregnancy Loss; PART 7: RHEUMATOLOGIC DISEASES; 28. Immunology and Immunogenetics; 29. Rheumatoid Arthritis; 30. Seronegative Spondyloarthropathies; 31. Genetics of Systematic Lupus Erythematosus; 32. Genetic Basis of Primary Osteoarthritis; 33. Common Disorders of Connective Tissue; PART 8: CANCER; 34. Gastrointestinal Cancer; 35. Breast Cancer; 36. Familial and Genetic Influences on Risk of Lung Cancer; 37. Reproductive Organ Cancers; 38. Skin Cancer; 39. Prostate Cancer; 40. Haematologic Cancer; PART 9: NEUROPSYCHIATRIC DISORDERS; 41. Epilepsy; 42. Multiple Sclerosis; 43. Alzheimer's Disease; 44. Affective Disorders; 45. Schizophrenia; 46. Alcoholism; 47. Mental Retardation; 48. Hereditary Hearing Loss; 49. Migraine; PART 10: OTHER COMMON PROBLEMS; 50. Common Skin Disease; 51. Genetic Modulation of Aging and Longevity; 52. Mitochondrial Defects in Common Diseases; 53. Constitutional Chromosome Disorders in Adults; PART 11: THERAPY; 54. Genetic Consequences of Modern Therapeutics: Iatrogenic Mutagenesis; 55. Pharmacogenetics, Ecogenetics and Pharmacogenomics